Xcopri moa?

Xcopri (cenobamate) is thought to work via two main mechanisms:

- Positive allosteric modulation of GABA_A receptors → enhances inhibitory GABAergic neurotransmission.
- Inhibition of voltage-gated sodium channels, especially the persistent sodium current (INaP) → reduces neuronal excitability and high-frequency firing.

The exact mechanism isn’t fully understood, and other contributions to its anticonvulsant effect may exist. It’s approved as adjunctive therapy for partial-onset seizures in adults.