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See the DrugPatentWatch profile for Xcopri
Xcopri (cenobamate) is thought to work via two main mechanisms: - Positive allosteric modulation of GABA_A receptors → enhances inhibitory GABAergic neurotransmission. - Inhibition of voltage-gated sodium channels, especially the persistent sodium current (INaP) → reduces neuronal excitability and high-frequency firing. The exact mechanism isn’t fully understood, and other contributions to its anticonvulsant effect may exist. It’s approved as adjunctive therapy for partial-onset seizures in adults.
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