What percentage of people gain weight on lyrica?

How common is weight gain with Lyrica (pregabalin)?

In the prescribing information, weight gain is reported as a side effect in about 2% of people taking Lyrica (pregabalin). [1]

Is the “weight gain” number different depending on dose or study type?

The figure above is the labeled percentage for weight gain as an adverse reaction. The exact rates can vary across clinical trials and depending on the population studied, but the commonly cited labeled incidence is about 2%. [1]

What should patients watch for?

If weight gain happens on Lyrica, it can be noticeable over weeks to months. Patients who develop rapid or significant weight increase, swelling (especially in the legs), or worsening shortness of breath should contact a clinician, since weight gain can overlap with fluid retention in some people. [1]

Sources

1. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=022121