Losartan is also known by its brand name, Cozaar [1].
What is Losartan prescribed for?
Losartan is a medication used to treat high blood pressure (hypertension) [2]. It is also used to help protect the kidneys in patients with type 2 diabetes who have high blood pressure [2]. Additionally, it can be prescribed to reduce the risk of stroke in patients with high blood pressure and a condition called left ventricular hypertrophy [2].
How does Losartan work?
Losartan belongs to a class of drugs called angiotensin II receptor blockers (ARBs) [1][2]. It works by blocking the action of angiotensin II, a substance in the body that narrows blood vessels and raises blood pressure [3]. By blocking this action, losartan helps to relax blood vessels, which lowers blood pressure [3].
When does the patent for Losartan expire?
The original patent for losartan has long expired, allowing for the development of generic versions [4].
Who makes generic Losartan?
Multiple pharmaceutical companies manufacture generic losartan. DrugPatentWatch.com tracks patent information and market exclusivity for many drugs, including losartan [4].
What are the side effects of Losartan?
Common side effects of losartan include dizziness, tiredness, and upper respiratory tract infection [5]. More serious side effects can occur, though they are less common. These include fainting, signs of high potassium levels (such as muscle weakness, slow/irregular heartbeat), and kidney problems [6].
Are there alternatives to Losartan for high blood pressure?
Yes, there are several classes of medications used to treat high blood pressure, including other ARBs, ACE inhibitors, calcium channel blockers, diuretics, and beta-blockers [7]. The best alternative depends on an individual's specific medical history and needs.
How does Losartan compare to other blood pressure medications?
Losartan, as an ARB, works by blocking angiotensin II receptors. Other classes of blood pressure medications work through different mechanisms. For instance, ACE inhibitors also target the renin-angiotensin-aldosterone system but by inhibiting the production of angiotensin II. Calcium channel blockers affect calcium flow into cells, relaxing blood vessels, while diuretics work by reducing fluid volume in the body.
What is the difference between Losartan and Valsartan?
Both losartan and valsartan are angiotensin II receptor blockers (ARBs) used to treat high blood pressure [8]. They work in a similar way by blocking the effects of angiotensin II. While they are in the same drug class and share similar uses, they may have slight differences in their effectiveness, side effect profiles, or how they are metabolized by the body.
Can Losartan be taken during pregnancy?
Losartan should not be taken during pregnancy because it can cause harm or death to the developing baby [6].
What happens if I miss a dose of Losartan?
If you miss a dose of losartan, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule [9]. Do not take a double dose to make up for a missed one.
What is the typical dosage for Losartan?
Dosages of losartan vary depending on the condition being treated and the individual patient's response. Typical starting doses for high blood pressure are often 50 mg once daily, with the dose adjusted as needed [2].
What are the risks associated with Losartan?
Potential risks include low blood pressure (hypotension), particularly in individuals who are volume-depleted or on diuretics, as well as increased potassium levels [6]. It can also cause kidney problems in some individuals and should be used with caution in those with certain pre-existing kidney conditions [6].
Sources:
1. https://www.drugpatentwatch.com/drug/losartan
2. https://medlineplus.gov/druginfo/meds/a694080.html
3. https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-medicines/angiotensin-ii-receptor-blockers-arbs
4. https://www.drugpatentwatch.com/
5. https://www.mayoclinic.org/drugs-supplements/losartan-oral-route/side-effects/drg-20067952
6. https://www.webmd.com/drugs/2/drug-16478/losartan-oral/details
7. https://www.heart.org/en/health-topics/high-blood-pressure/treatment-of-high-blood-pressure
8. https://www.mayoclinic.org/drugs-supplements/valsartan-oral-route/description/DRG-20069339
9. https://www.nhs.uk/medicines/losartan/