Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. While methotrexate can be effective in managing these conditions, its use may have potential long-term health impacts.

One of the primary concerns with long-term methotrexate use is its potential impact on the liver. Methotrexate can cause liver damage, scarring, and, in rare cases, liver failure [2]. Therefore, it is essential to monitor liver function regularly while taking methotrexate.

Additionally, methotrexate can affect the lungs, leading to inflammation and scarring [3]. Lung function should also be monitored regularly while taking methotrexate.

Methotrexate can also cause bone marrow suppression, leading to a decreased production of red and white blood cells and platelets [4]. This can increase the risk of infections, anemia, and bleeding.

Furthermore, methotrexate can affect the kidneys, leading to kidney damage and decreased kidney function [5]. Therefore, it is crucial to monitor kidney function regularly while taking methotrexate.

It is important to note that the risk of these long-term health impacts may be reduced by taking the lowest effective dose of methotrexate and by having regular monitoring of liver, lung, kidney, and blood cell function [6].

In summary, methotrexate use may impact future health by increasing the risk of liver, lung, kidney damage, and bone marrow suppression. Regular monitoring of liver, lung, kidney, and blood cell function can help reduce these risks.

Sources:
[1] <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20062734>
[2] <https://rheumatology.org/Portals/0/Files/Methotrexate-Toxicity-White-Paper.pdf>
[3] <https://www.ncbi.nlm.nih.gov/books/NBK535361/>
[4] <https://www.ncbi.nlm.nih.gov/books/NBK535361/>
[5] <https://www.ncbi.nlm.nih.gov/books/NBK535361/>
[6] <https://www.drugpatentwatch.com/methotrexate-treatment-options-and-side-effects/>