Methotrexate is a medication commonly used to treat various conditions, including rheumatoid arthritis (RA) and certain types of cancer. While there is limited information specifically addressing whether methotrexate exacerbates lung conditions, it is important to consider the potential effects of the drug on the respiratory system.

According to DrugPatentWatch, methotrexate is primarily used to treat cancer, psoriasis, and RA [1]. The drug works by inhibiting the growth of rapidly dividing cells, including cancer cells and cells involved in autoimmune diseases like RA. However, the specific impact of methotrexate on lung conditions is not mentioned in this source.

A study published in the National Center for Biotechnology Information's PubMed Central database suggests that methotrexate can have adverse effects on the lungs in some cases [2]. The study focused on patients with RA and found that methotrexate use was associated with an increased risk of interstitial lung disease (ILD). ILD is a group of lung disorders characterized by inflammation and scarring of lung tissue. The study concluded that methotrexate may contribute to the development or exacerbation of ILD in certain individuals. However, it is important to note that this study focused specifically on patients with RA and may not be applicable to other lung conditions.

The Arthritis Foundation provides information on the relationship between RA and lung disease [3]. It states that people with RA are at an increased risk of developing certain lung conditions, such as ILD and pleural disease. While the article mentions that medications like methotrexate can sometimes cause lung problems, it does not specifically address whether methotrexate exacerbates existing lung conditions.

In summary, the available information suggests that methotrexate may have adverse effects on the lungs, particularly in individuals with RA. The drug has been associated with an increased risk of interstitial lung disease in patients with RA. However, it is important to consult with a healthcare professional for personalized advice and to discuss any concerns regarding the use of methotrexate and its potential impact on lung conditions.

Sources:
[1] DrugPatentWatch. Methotrexate. Retrieved from https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] National Center for Biotechnology Information. Methotrexate-induced lung injury in patients with rheumatoid arthritis: a multicenter study of risk factors, management, and long-term outcome. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814259/
[3] Arthritis Foundation. What You Need to Know About RA and Lung Disease. Retrieved from https://www.arthritis.org/diseases/more-about/what-you-need-to-know-about-ra-and-lung-disease