Tigecycline is an antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections, and community-acquired bacterial pneumonia [1][2]. As with many medications, tigecycline use can result in several side effects.

Common tigecycline side effects include nausea and vomiting, which are reported in more than 1 in 10 people [1][2]. Diarrhea is another common side effect, experienced by up to 1 in 10 people [1]. Additionally, changes in liver function tests have been observed in some patients taking tigecycline [1].

Less common side effects, occurring in up to 1 in 100 people, include headache, insomnia, and dizziness [1]. Rare side effects, affecting fewer than 1 in 1,000 people, consist of allergic reactions, anemia, and changes in heart rate [1].

It is essential to note that tigecycline may also cause severe side effects, such as severe diarrhea due to Clostridioides difficile infection, which can occur during or after treatment [1][2]. Moreover, tigecycline has been associated with an increased risk of death compared to other antibiotics in treating certain infections [2].

Healthcare professionals should carefully weigh the risks and benefits of tigecycline treatment and closely monitor patients for potential side effects [2]. Patients should consult their healthcare provider if they experience any side effects or have concerns about their medication [1].

Sources:

[1] DrugPatentWatch. Tigecycline. <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>

[2] Mayo Clinic. Tigecycline (Intravenous route). Side effects. <https://www.mayoclinic.org/drugs-supplements/tigecycline-intravenous-route/side-effects/drg-20072556>

[3] Liu, C. et al. Tigecycline: a review of its use in the treatment of intra-abdominal infections. Infectious Disease Therapy. 2015; 4: 1-14. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426172/>