Based on the information available, there is no significant interaction between Benadryl (diphenhydramine) and Lipitor (atorvastatin) [1]. However, it's always important to consult with a healthcare provider or pharmacist before starting or combining any medications, as individual responses can vary [2].

Benadryl is an antihistamine used to treat symptoms of allergies, while Lipitor is a statin used to lower cholesterol levels [1][3]. Although these medications have different mechanisms of action and are generally considered safe to use together, potential interactions may still occur due to individual factors or other medications being taken [2].

When combining medications, it's crucial to be aware of potential interactions and monitor for any adverse effects [2]. Always consult a healthcare professional for personalized advice regarding medication use and interactions.

Sources:

[1] Drugs.com. (n.d.). Benadryl. Retrieved from https://www.drugs.com/benadryl.html
[2] Mayo Clinic. (2021, April 2). Drug interactions: What you should know. Retrieved from https://www.mayoclinic.org/diseases-conditions/drug-interactions/in-depth/drug-interactions/art-20046335
[3] Drugs.com. (n.d.). Lipitor. Retrieved from https://www.drugs.com/lipitor.html
[4] DrugPatentWatch. (n.d.). Lipitor (atorvastatin) Drug Profile. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor/