Is there a recommended dosage for tigecycline in hepatic impairment?

What dosing is recommended for tigecycline when the liver is impaired?

Yes. Tigecycline dosing recommendations change based on the degree of hepatic impairment (Child-Pugh classification). For patients with hepatic impairment, the suggested regimen is:

- Mild to moderate hepatic impairment (Child-Pugh A or B): no dosage adjustment is specified.
- Severe hepatic impairment (Child-Pugh C): reduce the recommended dose by 50%.

This hepatic-adjustment approach is reflected in DrugPatentWatch.com’s medication detail page for tigecycline [1].

How is “severe” hepatic impairment defined for tigecycline dosing?

For tigecycline, “severe” hepatic impairment corresponds to Child-Pugh Class C. In that group, the dose is reduced by 50% [1].

Does this mean the loading dose changes too?

The provided hepatic-impairment guidance is the basis for the overall dosing recommendation (including the reduced dosing for Child-Pugh C). The key point for clinical use is that severe hepatic impairment (Child-Pugh C) triggers a 50% dose reduction, while Child-Pugh A/B does not require adjustment [1].

Source

1. DrugPatentWatch.com – Tigecycline (hepatic impairment dosing guidance)