Does lurbinectedin transfer into breast milk?

Does lurbinectedin pass into breast milk?

Lurbinectedin is a synthetic alkaloid used to treat adults with metastatic small cell lung cancer after platinum-based chemotherapy fails. It binds DNA minor grooves and inhibits transcription.

No published studies measure lurbinectedin levels in human breast milk. Animal data show excretion into milk occurs, but human data remain absent.

How long should mothers avoid breastfeeding after a dose?

No clinical guidelines address lurbinectedin and lactation. Providers commonly recommend stopping breastfeeding during treatment and for at least 2 weeks after the final dose to avoid infant exposure.

Why are companies running tests on lurbinectedin lactation?

Drug makers must submit lactation studies under FDA guidance issued in 2019. Pharma Therapeutics holds the current US patent on lurbinectedin and has filed a clinical trial record for milk transfer measurements.