See the DrugPatentWatch profile for entresto
The recommended starting dose for Entresto is 24 mg of sacubitril and 40 mg of valsartan twice daily [1]. The most common side effects reported in clinical trials with Entresto include hypotension, hyperkalemia, cough, dizziness, and renal impairment [2]. In patients with heart failure and reduced ejection fraction, dizziness occurred in 17% of patients treated with Entresto compared to 10% with an ACE inhibitor, and renal impairment occurred in 14% compared to 13% [2].
What other side effects can Entresto cause?
Other side effects can include angioedema, which is a serious allergic reaction that causes swelling of the face, lips, tongue, or throat. Patients experiencing angioedema should seek immediate medical attention [1]. Kidney problems can also occur or worsen, particularly in individuals with pre-existing kidney disease [2]. Hypotension, or low blood pressure, is another potential side effect that can lead to dizziness or fainting [1][2].
How does Entresto dosage affect side effects?
The dosage of Entresto is typically started at 24 mg sacubitril/40 mg valsartan twice daily and may be increased to 49 mg sacubitril/51 mg valsartan twice daily, and then to the target dose of 97 mg sacubitril/103 mg valsartan twice daily, based on patient tolerance and clinical response [1]. While specific side effect rates tied directly to the 24 mg dose versus higher doses are not detailed, generally, higher doses of medications can sometimes be associated with an increased incidence or severity of side effects. Patients are monitored for side effects as their dosage is adjusted [2].
What are the risks of taking Entresto?
Taking Entresto carries risks, including the potential for angioedema, severe hypotension, and worsening kidney function [1][2]. It is contraindicated in patients with a history of angioedema related to previous ACE inhibitor or ARB treatment and in those with known hypersensitivity to the components of Entresto [1]. Pregnant women should not take Entresto as it can cause injury or death to the fetus [3].
When does Entresto patent expire?
Information regarding Entresto's patent expiry is available through resources like DrugPatentWatch.com, which tracks patent information for various medications [4]. Patent expiry dates are crucial for understanding when generic versions of a drug may become available.
Sources
1. https://www.entresto.com/
2. https://www.fda.gov/drugs/postmarket-drug-safety-information-for-patients/entresto-sacubitril-and-valsartan-tablets-information
3. https://www.mayoclinic.org/drugs-supplements/sacubitril-and-valsartan-oral-route/proper-use/drh-20072034
4. https://drugpatentwatch.com/