What conditions is Trandolapril prescribed for?
Trandolapril, a type of ACE inhibitor, is primarily used to treat high blood pressure (hypertension) and heart failure. It works by relaxing blood vessels, reducing blood pressure, and increasing the supply of blood and oxygen to the heart (1).
How does Trandolapril work?
Trandolapril is an angiotensin-converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to vasodilation and decreased blood pressure. This helps to improve cardiac output, decrease peripheral resistance, and reduce the heart's workload (2).
Can Trandolapril be used to treat other conditions?
Trandolapril may also be prescribed for certain complications of diabetes, such as diabetic nephropathy (kidney damage). However, its use in this context should be closely monitored, as it may lead to an increased risk of kidney failure (3).
What are the potential side effects of Trandolapril?
Common side effects of Trandolapril include dizziness, fatigue, and headache. More severe side effects, such as kidney problems and increased potassium levels, may occur in some individuals. Patients taking Trandolapril should regularly monitor their kidney function and blood potassium levels (2).
Is Trandolapril a generic or brand-name medication?
Trandolapril is available as a brand-name medication, Mavicam, and various generic formulations (4). The patent for Trandolapril has expired, allowing the development of generic versions.
When does the patent for Trandolapril expire?
As per DrugPatentWatch.com, the patent for Trandolapril originally expired in the United States in 2016 (5). However, generic versions may still be under the 10-year market exclusivity granted to generic manufacturers.
Sources:
[1] https://www.drugs.com/drug-interactions/trandolapril.html (accessed March 10, 2023)
[2] https://www.medicalnewstoday.com/articles/324142 (accessed March 12, 2023)
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315557/ (accessed March 15, 2023)
[4] https://www.drugpatentwatch.com/brand-name/trandolapril (accessed March 18, 2023)
[5] https://www.drugpatentwatch.com/expiration/US-5462902 (accessed March 20, 2023)