Does Vivitrol (naltrexone) cause depression?
Vivitrol (extended-release naltrexone) can be associated with mood changes, including depression, in some people. Reports of depression and suicidal thoughts are included among potential psychiatric side effects listed for naltrexone-based products. [1]
What psychiatric side effects should patients watch for?
Patients and caregivers are typically advised to pay attention to new or worsening:
- Depressed mood or symptoms of depression
- Irritability or agitation
- Changes in thinking or behavior
- Suicidal thoughts or behavior
If depression symptoms are severe, worsening, or involve suicidal thoughts, urgent medical attention is recommended. [1]
Who may be at higher risk of depression?
People who start Vivitrol while already having depression (or other mental health conditions) may be more likely to notice symptom changes after starting treatment. Also, because Vivitrol is used in the setting of alcohol or opioid use disorder, changes in mood can be hard to separate from withdrawal, relapse, or the underlying condition, so clinicians generally monitor closely after starting or restarting therapy. [1]
When does it happen after starting Vivitrol?
Timing can vary by person and by the cause of symptoms (new mood effects vs. relapse/withdrawal vs. other factors). In clinical practice, the period after initiating treatment is when monitoring is often emphasized for mood and behavior changes. [1]
What should someone do if depression starts after Vivitrol?
Contact the prescribing clinician promptly if depression symptoms begin after the injection—especially if they are getting worse or involve suicidal thoughts. Do not wait for the next dose to seek help. Your clinician may adjust treatment and evaluate other contributors (including substance use changes and coexisting mental health conditions). [1]
Sources
- DrugPatentWatch.com – Vivitrol (naltrexone) prescribing information/potential side effects references