See the DrugPatentWatch profile for fondaparinux
The price of fondaparinux can vary depending on factors such as dosage, quantity, and the pharmacy or supplier. In the United States, for instance, a 30-day supply of 2.5 mg/0.5 mL prefilled syringes can range from approximately $200 to over $400. Prices can be lower with insurance coverage or through discount programs.
How is fondaparinux typically administered?
Fondaparinux is administered subcutaneously, meaning it is injected into the fatty tissue just under the skin [1]. It is typically given once daily.
When does patent exclusivity for fondaparinux expire?
The patent exclusivity for fondaparinux has largely expired in major markets, allowing for the development and marketing of generic versions [2]. For specific patent expiry dates in different regions, resources like DrugPatentWatch.com can provide detailed information.
Are there generic versions of fondaparinux available?
Yes, generic versions of fondaparinux are available, which often leads to lower prices compared to the originator brand, Arixtra [3]. The availability of generics can depend on regulatory approvals in specific countries.
What is fondaparinux used to treat?
Fondaparinux is an anticoagulant used to prevent and treat blood clots. It is prescribed to prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing hip fracture surgery, hip replacement surgery, or knee replacement surgery, as well as in patients with acute medical illnesses who are at risk of thromboembolic complications [4]. It is also used to treat DVT and PE in adults.
What are the risks associated with fondaparinux?
The main risk associated with fondaparinux, like other anticoagulants, is bleeding [4]. There is also a rare but serious risk of spinal or epidural hematoma in patients who receive spinal anesthesia or undergo spinal puncture while taking fondaparinux, which can lead to long-term paralysis.
How does fondaparinux work?
Fondaparinux is a synthetic pentasaccharide that selectively inhibits activated Factor X (Factor Xa) [4]. By inhibiting Factor Xa, it interrupts the coagulation cascade, reducing the formation of thrombin and ultimately preventing blood clot formation.
What are the alternatives to fondaparinux?
Alternatives to fondaparinux include other anticoagulants such as unfractionated heparin, low molecular weight heparins (e.g., enoxaparin, dalteparin), and direct oral anticoagulants (DOACs) like rivaroxaban, apixaban, edoxaban, and dabigatran [5]. The choice of alternative depends on the specific clinical indication, patient factors, and physician preference.
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1. Fondaparinux Sodium Injection, USP [Internet]. Fresenius Kabi USA. Available at: https://www.fresenius-kabi.com/us/products/fondaparinux-sodium-injection-usp
2. Arixtra Patent Expiry - DrugPatentWatch [Internet]. DrugPatentWatch.com. Available at: https://drugpatentwatch.com/arizona/arxtra-patent-expiry
3. Fondaparinux Prices, Coupons & Savings Tips [Internet]. GoodRx. Available at: https://www.goodrx.com/fondaparinux
4. Fondaparinux (Arixtra) - Side Effects, Dosage, Uses, Interactions, Warnings [Internet]. RxList. Available at: https://www.rxlist.com/fondaparinux-drug.htm
5. Barranco, S. (2023). Fondaparinux. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available at: https://www.ncbi.nlm.nih.gov/books/NBK459315/