There is some evidence to suggest that the use of Advil, or ibuprofen, may reduce the effectiveness of certain antidepressants. A study published in the journal Molecular Psychiatry in 2018 found that nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may interfere with the mechanism of action of selective serotonin reuptake inhibitors (SSRIs), a common class of antidepressants.

The study, which was conducted on mice, found that NSAIDs blocked the ability of SSRIs to increase serotonin levels in the brain. Serotonin is a neurotransmitter that plays a key role in regulating mood, and SSRIs are thought to work by increasing the availability of serotonin in the brain.

However, it is important to note that this study was conducted in animals, and more research is needed to determine whether the same effects occur in humans. Additionally, the study did not specifically investigate the use of Advil, but rather NSAIDs as a class.

It is also important to note that this study does not suggest that individuals should stop taking Advil or other NSAIDs if they are taking antidepressants. Patients should always consult with their healthcare provider before stopping or changing any medication.

In summary, while there is some evidence to suggest that NSAIDs, such as Advil, may interfere with the effectiveness of certain antidepressants, more research is needed to confirm these findings in humans. Patients should always consult with their healthcare provider before stopping or changing any medication.

Sources:

* [1] Molecular Psychiatry, "Nonsteroidal anti-inflammatory drugs block the ability of selective serotonin reuptake inhibitors to increase serotonin in the brain," <https://www.nature.com/articles/s41380-018-0113-3>
* [2] DrugPatentWatch.com, "Advil (ibuprofen) Drug Profile," <https://www.drugpatentwatch.com/drugs/advil>