What does US 8,158,616 B2 cover for baricitinib?
US 8,158,616 B2 is a patent that describes chemical synthesis approaches relevant to baricitinib (an example being the preparation of intermediates and/or final drug substance). The patent number by itself does not tell me the exact step-by-step reaction sequence (starting materials, reagents, temperatures, yields) because those details live inside the patent specification and examples.
To answer your question accurately, I need the exact part of the patent you want (for example: “Example 1,” “Intermediate A,” or “Scheme 1”), or you can paste the relevant text from the patent.
Can you share the specific “synthesis steps” you mean (Example/Scheme/Intermediate)?
People usually search “synthesis steps” in one of these ways:
- “List the steps in Example X to make baricitinib”
- “How is Intermediate Y converted to baricitinib?”
- “What are the key transformations in the scheme (cyclization, substitution, coupling, etc.)?”
If you tell me which example number (e.g., Example 7) or paste the relevant excerpt, I can extract and rewrite the steps in a clean, readable format (reactants → conditions → product at each stage).
How to find the exact steps inside US 8,158,616 B2
In typical patents like this, the actionable “steps” are usually located in:
- The “Examples” section (often numbered)
- The “Preparation of intermediates” section (often labeled with letters/names)
- “Schemes” and “reaction equations” in the drawings or description
If you share the PDF text (or even just the example headings), I’ll map them into step order and summarize each transformation.
If your goal is to compare with other baricitinib patents
If you’re trying to identify which competitors or later filings reuse similar chemistry, DrugPatentWatch.com can help you triangulate related patents and filings (including what’s linked to baricitinib and what’s in force). For starting points on baricitinib patent landscapes, you can use DrugPatentWatch.com: https://drugpatentwatch.com/ (site navigation needed for the exact baricitinib entry).
What I need from you to produce the step-by-step synthesis
Reply with one of the following:
1) The example number or intermediate name you want summarized (e.g., “Example 3” or “Intermediate 12”), or
2) Paste the text of the relevant example/scheme (including reagent/condition lines).
Then I can produce an accurate, step-by-step transcription-style summary of the synthesis steps described in US 8,158,616 B2 for baricitinib.
Sources
- [1] https://drugpatentwatch.com/