See the DrugPatentWatch profile for Naprosyn
Naprosyn CR is the brand name for a controlled‑release formulation of naproxen (a non‑steroidal anti‑inflammatory drug, NSAID). Below is a quick reference for most people who are looking for the basics. If you need personal dosing or have a specific medical question, it’s always best to check with your prescriber or pharmacist.
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What it’s used for
| Condition | Typical use in Naprosyn CR |
|-----------|----------------------------|
| Osteoarthritis | Reduce pain and stiffness |
| Rheumatoid arthritis | Control joint pain and inflammation |
| Ankylosing spondylitis | Reduce pain & stiffness |
| General musculoskeletal pain | Temporary relief |
| Menstrual pain (rarely) | Short‑term use |
The CR formulation is designed so the drug is released slowly over many hours, allowing fewer doses per day (usually twice a day).
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Typical adult dosing
- Standard dose: 550 mg once or twice daily
- Maximum daily dose: 1100 mg (split into 2 doses)
- Take with food or milk to reduce stomach irritation.
- Avoid alcohol while taking NSAIDs to lessen GI risk.
Your prescriber may adjust the dose for weight, kidney function, or severity of disease.
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How it works
Naproxen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, reducing prostaglandin production. That lowers inflammation, pain, and fever.
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Common side effects
- Gastro‑intestinal: nausea, heartburn, stomach pain, diarrhea, constipation
- Headache / dizziness
- Skin reactions: rash, itching
- Fluid retention: swelling (especially in ankles/feet)
- In rare cases: high blood pressure, kidney problems, or severe GI bleeding
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When to avoid or use with caution
| Situation | Why |
|-----------|-----|
| History of ulcers, GI bleeding, or serious GI disease | Naproxen can worsen ulcers or cause bleeding. |
| Kidney impairment | NSAIDs can reduce kidney perfusion. |
| Heart disease / high blood pressure | NSAIDs can worsen hypertension and increase cardiovascular risk. |
| Bleeding disorders / anticoagulants | Higher risk of bleeding. |
| Pregnancy (especially 3rd trimester) | Can cause fetal ductus arteriosus closure. |
| Concurrent use of other NSAIDs or steroids | Adds cumulative GI and cardiovascular risk. |
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Drug interactions (non‑exhaustive)
- Anticoagulants (warfarin, DOACs): ↑ bleeding risk
- Other NSAIDs or steroids: ↑ GI irritation
- ACE inhibitors / ARBs: ↓ kidney function when combined with NSAIDs
- SSRIs / SNRIs: ↑ GI bleeding risk
- Digoxin: May increase digoxin levels
- Methotrexate: May increase toxicity
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Practical tips
- Take it as directed: Do not double up doses if you miss one.
- Eat well: A meal or a glass of milk can shield your stomach.
- Stay hydrated: Helps kidney function.
- Monitor for signs: Persistent stomach pain, black stools, swelling, or chest pain should prompt a medical review.
- Store: Keep in the original container, out of reach of children.
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Bottom line
Naprosyn CR is a convenient, longer‑acting naproxen that can help manage arthritis pain and other inflammatory conditions. While it’s effective, it comes with the typical NSAID risks—especially to the stomach, kidneys, and heart. Use the lowest effective dose, follow your healthcare provider’s instructions, and keep an eye out for any red‑flag symptoms. If you’re unsure about the right dose or whether this medication is safe for your specific situation, check in with your prescriber or a pharmacist.