Belatacept is this a biologic ?

Yes—belatacept is a biologic. It’s a recombinant fusion protein (a biologic drug) that consists of the extracellular domain of CTLA‑4 linked to the Fc portion of IgG1. By binding to CD80/86 on antigen‑presenting cells, it blocks the costimulatory signal needed for T‑cell activation, which helps prevent organ rejection (it’s approved for kidney transplant patients). So it’s a biologic, not a small‑molecule drug.