Cardene is a brand name for nicardipine, a calcium channel blocker used to treat high blood pressure and angina (chest pain) [1]. It works by relaxing blood vessels, which lowers blood pressure and improves blood flow to the heart [1].
How does Cardene work?
Cardene, containing the active ingredient nicardipine, is a dihydropyridine calcium channel blocker. It selectively inhibits the influx of calcium ions across the membranes of cardiac muscle and vascular smooth muscle cells without significantly affecting cardiac contractility [1]. By blocking calcium channels in the smooth muscle of blood vessel walls, nicardipine causes vasodilation, or widening of the blood vessels. This reduced peripheral vascular resistance leads to a decrease in blood pressure [1]. In patients with angina, this vasodilation also increases the supply of oxygen to the heart muscle, relieving chest pain [1].
When was Cardene first approved?
The U.S. Food and Drug Administration (FDA) first approved nicardipine hydrochloride, the active ingredient in Cardene, in the late 1980s [2].
What is the difference between Cardene and other blood pressure medications?
Cardene belongs to a class of drugs called calcium channel blockers. Unlike some other blood pressure medications such as diuretics that work by reducing fluid volume, or ACE inhibitors that target the renin-angiotensin system, Cardene directly affects the smooth muscle of blood vessels [1]. Other classes of antihypertensive drugs include beta-blockers, alpha-blockers, and angiotensin II receptor blockers (ARBs), each with distinct mechanisms of action [1].
Can Cardene be used for conditions other than high blood pressure and angina?
While Cardene's primary approved indications are hypertension and angina, healthcare providers may prescribe it off-label for other conditions where vasodilation is beneficial. However, the FDA has not approved it for these uses.
What are the potential side effects of Cardene?
Common side effects associated with Cardene include headache, dizziness, flushing, nausea, and peripheral edema (swelling in the ankles or feet) [1]. Less common but more serious side effects can occur, and patients should consult their doctor about any concerns [1].
When does the patent for Cardene expire?
Information regarding the specific patent expiration dates for brand-name Cardene is proprietary and subject to change. However, the active ingredient, nicardipine hydrochloride, has been available in generic form for many years, indicating that its primary patents have long expired [2]. DrugPatentWatch.com provides resources for tracking patent information for pharmaceuticals.
Who manufactures Cardene and its generic versions?
The original brand-name Cardene was developed and marketed by various pharmaceutical companies over time. Generic versions of nicardipine are manufactured by numerous pharmaceutical companies worldwide.