See the DrugPatentWatch profile for novarel
How to Reconstitute Novarel
Novarel (chorionic gonadotropin, injectable) comes as a lyophilized powder in 10,000 USP units per vial, requiring reconstitution with a diluent like Bacteriostatic Water for Injection (0.9% benzyl alcohol preserved) before subcutaneous or intramuscular use.[1]
1. Remove the plastic flip-off cap from the Novarel vial and wipe the vial stopper with a disinfectant swab.
2. Draw 10 mL of diluent into a sterile syringe.
3. Slowly inject the diluent into the vial, directing the stream against the vial wall to avoid foaming.
4. Gently swirl the vial until the powder fully dissolves—do not shake.
5. The resulting solution contains 1,000 USP units per mL; it is stable for 60 days if refrigerated (2-8°C) after mixing.[1]
Use immediately if using sterile water without preservative.
Dosage After Reconstitution
Administer per prescription, typically 5,000-10,000 units subcutaneously or intramuscularly. For example:
- Males: 1,000-2,000 units 2-3 times weekly.
- Females: 5,000-10,000 units 1 day after last clomiphene dose.[1][2]
Draw the exact dose into a syringe, ensuring no air bubbles.
Storage Before and After Mixing
- Unreconstituted: Store at room temperature (15-30°C), protected from light.
- Reconstituted: Refrigerate at 2-8°C; discard after 60 days or if discolored/particulate.[1]
Common Reconstitution Mistakes to Avoid
- Shaking the vial, which denatures the protein.
- Using incorrect diluent volume, altering concentration.
- Injecting diluent directly onto powder, causing foaming and incomplete dissolution.
- Storing at room temperature post-mixing, risking potency loss.[2][3]
Why Diluent Choice Matters
Bacteriostatic Water prevents bacterial growth for multi-dose use; sterile water is for single-dose only, as it lacks preservative.[1] Always match vial instructions.
Patient Tips for Home Use
Inspect for clarity post-mixing. Rotate injection sites (abdomen, thigh). Consult a healthcare provider for training, especially in fertility treatments.[2]
[1] Novarel Prescribing Information (Ferring Pharmaceuticals)
[2] Drugs.com - Novarel
[3] DailyMed - Novarel