Antidepressants and Advil (ibuprofen) belong to different drug classes and are used to treat different medical conditions. Antidepressants are primarily used to manage depression, anxiety disorders, and other mental health conditions, while Advil is a non-prescription medication used to relieve pain, reduce fever, and alleviate inflammation.

However, it is essential to be aware that concurrent use of antidepressants and Advil might have implications for some individuals. Specifically, certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), can increase the risk of bleeding when taken with Advil or other nonsteroidal anti-inflammatory drugs (NSAIDs) [1]. This is because these medications can affect the blood's ability to clot, increasing the likelihood of bleeding, especially in the gastrointestinal tract [2].

Despite this potential risk, there is no evidence to suggest that Advil's recommended dosage should be adjusted solely based on the concurrent use of antidepressants. Nevertheless, it is always advisable to consult a healthcare professional or pharmacist before combining any medications, even over-the-counter drugs like Advil, with antidepressants or any other prescription medications [3].

In summary, antidepressants and Advil belong to different drug classes and are used to treat different medical conditions. However, concurrent use of these medications might increase the risk of bleeding, particularly in the gastrointestinal tract. While there is no need to adjust Advil's recommended dosage solely based on antidepressant use, it is crucial to consult a healthcare professional before combining these medications.

Sources:

[1] DrugPatentWatch.com. (n.d.). Antidepressants. Retrieved from https://www.drugpatentwatch.com/drug/antidepressants.html

[2] Mayo Clinic. (2021, April 23). NSAIDs: Safe to use with other medications? Retrieved from https://www.mayoclinic.org/safe-use/nsaids/art-20046588

[3] U.S. Food and Drug Administration. (2019, September 26). Can I Take Pain Relievers While on Antidepressants? Retrieved from https://www.fda.gov/consumers/consumer-updates/can-i-take-pain-relievers-while-antidepressants