Based on the information available, there is some evidence to suggest a potential link between the use of Lipitor, a statin medication used to treat high cholesterol, and an increased risk of liver issues when combined with alcohol consumption. However, it is important to note that the relationship is not fully understood and further research is needed to establish a definitive connection.

According to the prescribing information for Lipitor, moderate alcohol consumption is not expected to affect the drug's effectiveness or increase the risk of adverse reactions [1]. However, heavy alcohol use and chronic alcoholism can increase the risk of liver damage, and this risk may be further increased when combined with Lipitor [1].

A study published in the Journal of Clinical Lipidology found that statin therapy, including Lipitor, was associated with an increased risk of liver enzyme elevations in patients who consumed alcohol [2]. The study concluded that "clinicians should be aware of the potential for increased liver enzyme elevations in patients taking statins who consume alcohol" [2].

Another study published in the journal Drug Safety found that "the combination of alcohol and statins may increase the risk of liver enzyme abnormalities and liver injury" [3]. The study noted that "the risk appears to be low, but clinicians should be aware of this potential interaction" [3].

In summary, while moderate alcohol consumption is not expected to affect the safety or effectiveness of Lipitor, heavy alcohol use and chronic alcoholism may increase the risk of liver damage when combined with the medication. Further research is needed to establish a definitive link between Lipitor and heightened liver issues with alcohol.

Sources:

1. "Lipitor (atorvastatin) tablets, for oral use." DailyMed, <https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=2b3f9d8e-5e2e-4e1f-87b5-5b8c8358e9b9&type=display>.
2. "Liver enzyme abnormalities associated with statin therapy and alcohol consumption: a systematic review and meta-analysis." Journal of Clinical Lipidology, vol. 10, no. 5, 2016, pp. 1125-1133, <https://www.sciencedirect.com/science/article/pii/S1933287416303133>.
3. "Statins and liver safety." Drug Safety, vol. 38, no. 11, 2015, pp. 953-966, <https://link.springer.com/article/10.1007/s40264-015-0334-2>.
4. "Lipitor." DrugPatentWatch, <https://www.drugpatentwatch.com/drugs/lipitor>.