Promethazine with codeine syrup, often referred to as "lean" or "purple drank," is a prescription medication. Its price can vary significantly based on several factors, including the pharmacy, insurance coverage, and geographic location [1]. Because it is a controlled substance, pricing is not always transparently published by all retailers in the same way as over-the-counter medications [2].
How much does promethazine with codeine syrup typically cost?
The cost of promethazine with codeine syrup for a prescription can range from approximately $20 to over $100 for a standard prescription bottle (e.g., 4 ounces or 16 ounces), especially without insurance [1][3]. Factors such as the specific formulation, manufacturer, and whether a generic version is available can influence the final price. Insurance plans can substantially reduce out-of-pocket costs, often to a co-pay amount [1].
Where can I get promethazine with codeine syrup?
Promethazine with codeine syrup is available by prescription only from licensed pharmacies. It is important to obtain this medication from a legitimate source with a valid prescription from a healthcare provider. Diversion and illicit sales of this substance are illegal and carry significant risks [4].
Why is promethazine with codeine syrup a controlled substance?
Promethazine with codeine syrup is classified as a Schedule V controlled substance by the U.S. Drug Enforcement Administration (DEA) due to the presence of codeine, an opioid agonist. Opioids have a potential for abuse and dependence. This classification imposes strict regulations on its manufacturing, distribution, prescription, and dispensing [5].
What are the risks associated with promethazine with codeine syrup?
The primary risks associated with promethazine with codeine syrup stem from its opioid component, codeine. These risks include respiratory depression, extreme drowsiness, constipation, nausea, and the potential for developing physical dependence and addiction [6]. Mixing it with other central nervous system depressants, such as alcohol or benzodiazepines, can significantly increase these risks, potentially leading to overdose or death [7].
Are there alternatives to promethazine with codeine syrup for cough relief?
For cough relief, various alternative medications are available that do not contain codeine. These include over-the-counter (OTC) cough suppressants containing dextromethorphan and expectorants like guaifenesin. Prescription-strength cough medicines without opioids are also available, which may involve different active ingredients or combinations [8].
Sources:
[1] GoodRx. (n.d.). Promethazine VC with codeine Prices, Coupons & Savings Tips. Retrieved from https://www.goodrx.com/promethazine-vc-with-codeine
[2] U.S. Food & Drug Administration. (n.d.). Controlled Substances. Retrieved from https://www.dea.gov/controlled-substances
[3] Drugs.com. (n.d.). Promethazine and Codeine Oral Syrup. Retrieved from https://www.drugs.com/mtm/promethazine-and-codeine-oral-syrup.html
[4] U.S. Drug Enforcement Administration. (n.d.). Drug Fact Sheets. Retrieved from https://www.dea.gov/drug-information
[5] U.S. Drug Enforcement Administration. (n.d.). Controlled Substances Act. Retrieved from https://www.dea.gov/drug-scheduling
[6] National Institute on Drug Abuse. (n.d.). Opioid Overdose. Retrieved from https://www.drugabuse.gov/drug-topics/opioids/opioid-overdose
[7] Substance Abuse and Mental Health Services Administration. (n.d.). Drug Overdose. Retrieved from https://www.samhsa.gov/data/drug-overdose-data
[8] National Institutes of Health. (n.d.). Cough. Retrieved from https://www.medlineplus.gov/cough.html