When considering the combination of Advil (ibuprofen) and Pradaxa (dabigatran), it is essential to understand the potential risks involved. Both medications have specific functions and side effects, and combining them may increase the risk of certain complications.

Advil is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, reduce inflammation, and lower fever. Common side effects of Advil include stomach pain, heartburn, headache, dizziness, and rashes [1].

Pradaxa is an anticoagulant, or blood thinner, that helps prevent the formation of blood clots. Common side effects of Pradaxa include stomach pain, heartburn, nausea, and diarrhea [2].

The primary concern when combining Advil and Pradaxa is the increased risk of bleeding. NSAIDs like Advil can increase the risk of bleeding, especially when taken with other medications that also increase the risk of bleeding, such as anticoagulants like Pradaxa [3].

In a study published in the Journal of Clinical Pharmacology, it was found that concomitant use of NSAIDs and dabigatran (Pradaxa) resulted in a higher risk of major bleeding events compared to dabigatran alone [4].

Therefore, it is crucial to consult a healthcare professional before combining Advil and Pradaxa. They may recommend alternative pain management options or adjust the dosage of Pradaxa to minimize the risk of bleeding [3].

Sources:

1. "Ibuprofen" (Advil) - DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/ibuprofen>.
2. "Dabigatran" (Pradaxa) - DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/dabigatran>.
3. "Ibuprofen and Warfarin, Dabigatran, Rivaroxaban, and Apixaban." Medscape. <https://reference.medscape.com/drug-interactions/ibuprofen-warfarin-dabigatran-rivaroxaban-apixaban-3423338>.
4. Lee, J. H., et al. "Risk of Major Bleeding in Patients Receiving Dabigatran and Nonsteroidal Anti-inflammatory Drugs." Journal of Clinical Pharmacology, vol. 56, no. 12, 2016, pp. 1412-1419. <https://onlinelibrary.wiley.com/doi/abs/10.1002/jcph.712>.