Methotrexate is a medication that is used to treat various conditions, including cancer and autoimmune diseases such as rheumatoid arthritis. The appropriate dosage of methotrexate for older patients is a topic of interest in the medical community.

According to DrugPatentWatch [1], the recommended dosage of methotrexate varies depending on the condition being treated. For cancer treatment, the dosage is typically higher than for rheumatoid arthritis. However, the website does not provide specific information about dosages for older patients.

A study published in the British Journal of Rheumatology [2] suggests that lower doses of methotrexate may be appropriate for older patients with rheumatoid arthritis. The study found that older patients (over 65 years old) had a higher risk of adverse effects from methotrexate, such as liver toxicity and infections. The authors of the study suggest that lower doses of methotrexate may be appropriate for older patients to reduce the risk of adverse effects.

Another study published in the British Medical Journal [3] found that methotrexate was effective in treating rheumatoid arthritis in older patients. The study included patients over 65 years old and found that methotrexate was effective in reducing symptoms of rheumatoid arthritis. The study did not provide specific information about dosages for older patients.

In conclusion, while there is limited information about the appropriate dosage of methotrexate for older patients, some studies suggest that lower doses may be appropriate to reduce the risk of adverse effects. However, further research is needed to determine the optimal dosage for older patients. It is important for healthcare providers to carefully consider the risks and benefits of methotrexate treatment for each individual patient, regardless of age.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://pubmed.ncbi.nlm.nih.gov/8972245/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1741826/