Does airduo contain fluticasone?

Does AirDuo contain fluticasone?

AirDuo is a dry powder inhaler containing fluticasone propionate and salmeterol. It is used twice daily for maintenance treatment of asthma in patients 12 and older.

Does fluticasone propionate work differently than fluticasone furoate?

Fluticasone propionate is the specific salt form in AirDuo. It is a synthetic corticosteroid that works inside the lungs to reduce inflammation. The furoate salt form appears in other inhalers like Breo and Arnuity. Both forms reduce asthma symptoms, but they differ in binding affinity and dosing frequency. Fluticasone propionate requires twice-daily dosing, whereas fluticasone furoate can sometimes on once-daily dosing in some devices.

What happens if you take fluticasone propionate twice daily?

Fluticasone propionate is dosed twice daily in AirDuo. That pattern is required to maintain steady levels inside the lungs. It does not require the patient to switch salt forms or change to once-daily dosing.

When does the AirDuo patent expire?

The composition-of-matter patent covering the inhaler device itself expired in 2018. The method-of-use patents for the combination of fluticasone propionate and salmeterol in a dry powder inhaler are scheduled to expire in 2025. [1]

When does exclusivity expire?

Exclusivity periods for AirDuo expired in 2019. Those periods protected the manufacturer from generic competition until that time. Generic versions of the combination inhaler are now available. [1]

Can biosimilars enter before patent expiry?

Biosimilars do not apply to small-molecule drugs like fluticasone propionate. Small-molecule products such like AirDuo have generics that compete after patent and exclusivity periods expire. [1]

Who manufactures AirDuo?

Teva Pharmaceuticals manufactures AirDuo. [1]

Who makes the generics?

Several companies produce generic versions of fluticasone propionate/salmeterol dry powder inhalers. Mylan, Sandoz, and others provide competitive alternatives. [1]

Why are companies challenging this patent?

Patent challenges were filed for certain method-of-use patents. The challenges helped drive generic entry once the method-of-use patents began to expire. [1]

[1] https://www.drugpatentwatch.com