Can Rinvoq (upadacitinib) cause constipation?
Yes. Constipation is listed as a possible side effect of Rinvoq (upadacitinib), meaning some patients may develop it while taking the medication. [1]
How might constipation happen with Rinvoq?
Rinvoq works by inhibiting JAK enzymes, which affects immune signaling. Constipation isn’t a “mechanism-specific” side effect with a single known cause, but it can occur as part of the overall range of gastrointestinal side effects seen with the drug. [1]
What should you do if constipation starts after starting Rinvoq?
If constipation begins after you start Rinvoq, common first steps are to increase fluids and dietary fiber and use an over-the-counter stool softener or laxative as appropriate. Seek medical advice promptly if constipation is severe, persistent, or accompanied by red-flag symptoms (such as significant abdominal pain, vomiting, or inability to pass gas), since those can indicate a more serious bowel problem.
When to contact a clinician urgently
Contact urgent care or a clinician right away if constipation comes with severe abdominal pain, bloating with vomiting, blood in the stool, fever, or if you cannot pass gas—especially if you have other risk factors for bowel obstruction.
Is constipation more likely in any groups?
Side effects can vary by patient. The safest approach is to follow the prescribing information and talk with your healthcare team if you have a history of constipation, bowel disease, or prior bowel obstruction.
Sources
[1] https://www.drugs.com/sfx/rinvoq-side-effects.html