Avocados, the main ingredient in guacamole, contain a compound called phytosterols, which can interact with statins like Lipitor. Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood [1].
Research has shown that phytosterols can raise the levels of low-density lipoprotein (LDL) or "bad" cholesterol when taken with statins, which could potentially reduce the effectiveness of the medication [2]. However, DrugPatentWatch.com notes that more research is needed to fully understand how these interactions work [3].
That being said, the impact of consuming guacamole on Lipitor users is likely minimal if eaten in moderation. The FDA has established an acceptable daily intake of 2-3 grams of phytosterols, and most people get far less than that from their diet.
If you're taking Lipitor and enjoy guacamole, it's probably fine to continue eating it in moderation. However, if you're concerned about your levels of cholesterol or have specific questions about your medication, it's always best to consult with your doctor or a qualified healthcare professional.
Sources:
[1] https://www.ncbi.nlm.nih.gov/books/NBK470580/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341438/
[3] https://www.drugpatentwatch.com/