Invokamet XR, a combination medication containing canagliflozin and metformin, can cause several side effects. Common adverse effects include diarrhea, nausea, vomiting, abdominal discomfort, loss of appetite, and a metallic taste in the mouth [1].
What are the serious side effects of Invokamet XR?
More serious side effects associated with Invokamet XR can include lactic acidosis, a rare but serious complication of metformin that can lead to death. Symptoms of lactic acidosis may include unusual muscle pain, trouble breathing, stomach pain, dizziness, or feeling very cold [1].
Canagliflozin, one of the active ingredients, carries a risk of ketoacidosis, a condition where the body produces high levels of blood acids called ketones. This can occur even in people with normal blood sugar levels and may require hospitalization. Signs of ketoacidosis include difficulty breathing, nausea, vomiting, stomach pain, fatigue, and fruity breath odor [1].
Invokamet XR can also increase the risk of serious urinary tract infections, including kidney infections and sepsis. Symptoms may include frequent urination, painful urination, or pain in the back or side [1].
Furthermore, canagliflozin has been associated with Fournier's gangrene, a rare but serious infection of the genitals and the area from the anus to the groin. Immediate medical attention is needed if symptoms such as severe pain, redness, swelling in the genital area, or fever occur [1].
Other potential serious side effects include dehydration, a drop in blood pressure, and an increased risk of bone fractures [1].
How does Invokamet XR work?
Invokamet XR combines two medications to lower blood sugar levels. Metformin works by decreasing the amount of glucose produced by the liver and reducing the absorption of glucose from the intestines. Canagliflozin belongs to a class of drugs called SGLT2 inhibitors, which work by preventing the kidneys from reabsorbing glucose, causing excess glucose to be eliminated from the body in the urine [1].
What are the contraindications for Invokamet XR?
Invokamet XR is contraindicated in patients with severe renal impairment, end-stage renal disease, or in patients with a history of lactic acidosis or diabetic ketoacidosis [1].
When does patent exclusivity expire for Invokamet XR?
Information on the specific patent expiry dates for Invokamet XR is available through resources like DrugPatentWatch.com [2].