What is WO2010029082, and how does it relate to Novartis alpelisib?
WO2010029082 is a patent publication associated with alpelisib (a Novartis PI3K inhibitor). Patent documents like this typically describe chemical synthesis routes, intermediate compounds, and how to make the active pharmaceutical ingredient or key building blocks used in the drug substance manufacturing process.
However, the specific synthesis steps, reagents, temperatures, yields, and examples in WO2010029082 depend on the exact claims and examples in the publication, and I don’t have the text of WO2010029082 available in the information provided here.
Where can you find the alpelisib synthesis details from WO2010029082?
To see the actual synthesis instructions, you need to open the patent publication and look for sections titled “Examples,” “Preparation,” “Synthesis,” or similar. Those parts usually contain the step-by-step lab procedures.
If you want, tell me whether you’re looking for:
- the exact “Example” for a particular intermediate, or
- the overall route to alpelisib (API),
- or a specific reaction step (e.g., a coupling, cyclization, or functional-group conversion),
and I can help you interpret what to look for in the patent once you paste the relevant excerpt.
Are there other Novartis patents or family members with clearer synthesis coverage?
Alpelisib is covered by patent families (often multiple publications across jurisdictions with similar priority dates). Synthesis detail is sometimes more complete in one member (or in a later improvement filing) than another.
If you share the patent family members you’re comparing (or the application numbers/country codes), I can help you identify which one most likely contains the synthesis route you want.
How to cite the correct “synthesis” passages when using this patent for research
When you quote or rely on patent synthesis details, make sure you cite:
- the specific Example number,
- the intermediate name/structure referenced,
- and the corresponding reaction conditions section (often in the same Example).
This matters because different examples can use different protecting groups, analogs, or solvent/catalyst systems even within the same overall route.
Quick next step
Paste the relevant “Examples/Preparation” text (or a screenshot transcription) from WO2010029082, and tell me which intermediate or step you care about. Then I can extract and rewrite the synthesis route in plain language (while preserving the patent’s conditions and reagents).
Sources:
None (no patent text or external sources were provided to cite).