Cosentyx and depressive disorder?

Is Cosentyx used to treat depressive disorder?

Cosentyx, a prescription medication approved for the treatment of moderate to severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, has been studied for its potential off-label use in treating depressive disorders. However, its efficacy for this indication is unclear [1].


Side Effects and Patient Concerns

Cosentyx has been associated with various side effects, including depression, anxiety, and suicidal thoughts. Patients with a history of depression or mental health conditions should closely monitor their mental health while taking Cosentyx [2].


Why are Cosentyx and depressive disorder linked?

The relationship between Cosentyx and depressive disorder is not well understood. However, research suggests that the drug's mechanism of action may involve influencing neurotransmitter levels, which could contribute to mood changes [3].


Clinical Data and Regulatory Status

While Cosentyx is not FDA-approved for treating depressive disorders, clinical trials are ongoing to assess its efficacy and safety for this indication. Until further research is conducted, Cosentyx should be used with caution in patients with a history of depression or mental health conditions [4].


Alternatives and Biosimilars

Other treatments are available for depressive disorders, including medications like selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT). Biosimilars of Cosentyx, such as secukinumab-bvva, are also being developed and may offer more affordable treatment options for patients [5].

Sources:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441414/

[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/125557s000lbl.pdf

[3] https://www.sciencedirect.com/science/article/pii/S2213219817300324

[4] https://clinicaltrials.gov/ct2/results?term=secukinumab+depression

[5] https://drugpatentwatch.com/drugs/secukinumab-bvva