Ondansetron is sold under the brand name Zofran.
What is Zofran used for?
Zofran is a medication prescribed to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery [1]. It works by blocking the action of a substance in the body called serotonin, which can trigger nausea and vomiting [1].
When does Zofran's patent expire?
The original patents for ondansetron have expired, allowing for the availability of generic versions of the drug [2]. Information on specific patent expiry dates can be found through resources like DrugPatentWatch.com [2].
Who manufactures Zofran?
Zofran was originally developed and marketed by GlaxoSmithKline (GSK) [3]. However, with the expiration of its primary patents, other pharmaceutical companies now produce and market generic versions of ondansetron.
What are the alternatives to Zofran?
Besides generic ondansetron, other antiemetic medications are available to manage nausea and vomiting, depending on the cause and severity. These may include other serotonin receptor antagonists, as well as different classes of drugs like dopamine antagonists or corticosteroids [1].
What are the side effects of ondansetron?
Common side effects of ondansetron can include headache, constipation, diarrhea, dizziness, and fatigue [1]. Less common but more serious side effects can also occur.
How does ondansetron work?
Ondansetron is a selective 5-HT3 receptor antagonist [1]. By blocking the activity of serotonin at these receptors in the gut and in the brainstem, it effectively reduces the stimulus that leads to nausea and vomiting [1].
Sources:
[1] Ondansetron - National Institute of Diabetes and Digestive and Kidney Diseases
[2] DrugPatentWatch.com
[3] GlaxoSmithKline