Ibuprofen, the active ingredient in Advil, has a side effect profile that can change with long-term use. While ibuprofen is generally well-tolerated for short-term use, potential risks can increase with long-term use [1].

Common side effects of ibuprofen include stomach pain, heartburn, nausea, and headaches [1]. These side effects are typically mild and can be managed with dosage adjustments or over-the-counter remedies.

However, long-term use of ibuprofen can increase the risk of more serious side effects. These include stomach ulcers, bleeding in the stomach and intestines, and kidney or liver damage [1][2]. In rare cases, long-term use of ibuprofen has been linked to an increased risk of heart attack or stroke [1].

It is important to note that the risk of these serious side effects increases with higher doses and longer durations of use [1]. Therefore, it is recommended to use the lowest effective dose for the shortest possible time [1].

Individuals with certain health conditions, such as heart disease, high blood pressure, or kidney or liver disease, may be at higher risk of serious side effects from ibuprofen [1]. It is important for these individuals to consult with their healthcare provider before using ibuprofen, especially for long-term use.

In summary, while ibuprofen is generally safe for short-term use, long-term use can increase the risk of more serious side effects. It is important to use the lowest effective dose for the shortest possible time and to consult with a healthcare provider before using ibuprofen for long-term use.

Sources:
[1] "Ibuprofen: MedlinePlus Drug Information." MedlinePlus, U.S. National Library of Medicine, 11 Jan. 2022, medlineplus.gov/druginfo/meds/a682135.html.
[2] "Ibuprofen." DrugPatentWatch, drugpatentwatch.com/ibuprofen.