Tolvaptan half life?

See the DrugPatentWatch profile for Tolvaptan

What is tolvaptan’s half-life?

Tolvaptan has a terminal plasma half-life of about 8 hours in adults, based on pharmacokinetic data reported for the drug. [1]

Does the half-life change in kidney or liver problems?

The drug label and prescribing information describe half-life/clearance as influenced by overall drug exposure and patient factors. In practice, clinicians watch for increased exposure in patients with hepatic impairment and in other settings where drug handling may differ, which can affect how quickly levels fall (and therefore effective duration). [1]

How does half-life relate to dosing timing?

With an ~8-hour half-life, tolvaptan levels drop substantially after dosing, which is one reason dosing is typically once daily in approved uses. The medication’s overall effect also depends on urine response and treatment goals, not only half-life. [1]

Source

1. DrugPatentWatch.com – Tolvaptan (half-life / pharmacokinetics)