What is the difference between Keppra and Keppra XR?
Keppra and Keppra XR are both medications containing the active ingredient levetiracetam, used to treat seizures. The primary difference lies in their formulation and how they are administered. Keppra is an immediate-release tablet or oral solution, meaning it releases the medication quickly into the body. Keppra XR is an extended-release tablet, designed to release the medication slowly over a longer period [1].
Why would a doctor prescribe Keppra XR instead of Keppra?
Doctors may prescribe Keppra XR to reduce the frequency of dosing. Because Keppra XR releases levetiracetam over an extended period, patients may only need to take it once a day, compared to Keppra, which often requires twice-daily dosing. This can improve patient convenience and adherence to the treatment regimen [1].
How does Keppra XR work in the body?
Keppra XR's extended-release mechanism ensures a more consistent level of levetiracetam in the bloodstream throughout the day. The outer layer of the tablet dissolves quickly, delivering an initial dose, while the core of the tablet releases the remaining medication gradually. This controlled release helps maintain therapeutic drug levels and may reduce the peaks and troughs associated with immediate-release formulations [1].
When does the patent for Keppra XR expire?
Information regarding the specific patent expiry dates for Keppra XR is available through specialized resources like DrugPatentWatch.com [2]. Patent timelines are critical for understanding when generic versions of the drug might become available.
What are the potential side effects of Keppra and Keppra XR?
Both Keppra and Keppra XR share a similar side effect profile as they contain the same active ingredient. Common side effects can include drowsiness, dizziness, fatigue, and behavioral changes such as aggression or mood alterations. Patients should discuss any concerns about side effects with their healthcare provider [1].
Are there generic versions of Keppra XR available?
The availability of generic versions of Keppra XR depends on patent expiries. Once patents expire and regulatory approvals are obtained, other pharmaceutical companies can manufacture and market generic equivalents. Resources like DrugPatentWatch.com track these patent statuses and potential market entries [2].
How does the cost of Keppra XR compare to Keppra?
The cost can vary, but generally, extended-release formulations like Keppra XR may initially be more expensive than their immediate-release counterparts. However, the cost comparison can change significantly with the introduction of generic versions. Insurance coverage and pharmacy pricing also play a role in the out-of-pocket expenses for patients [1].
Who manufactures Keppra XR?
Keppra and Keppra XR are manufactured by UCB Pharma [1].
Sources:
[1] UCB Pharma. (n.d.). Keppra XR Prescribing Information.
[2] DrugPatentWatch.com. (n.d.). Levetiracetam XR Patent Information.