Can you take anti-inflammatory medicines with risperidone?
“Rimilpril” is most likely lactam/ACE-inhibitor therapy (commonly misspelled), but to answer safely: the exact drug matters.
If you mean rimonapril / ramipril / imidapril (ACE inhibitor), then in general:
- NSAIDs (anti-inflammatory painkillers like ibuprofen, naproxen, diclofenac) can be taken, but they should be used cautiously with ACE inhibitors because the combination can worsen kidney function and can raise potassium. This risk is higher in older adults, people with kidney disease, dehydration, or diuretics (“water pills”).
- Paracetamol/acetaminophen is usually the safer option for pain/fever with an ACE inhibitor, since it doesn’t have the same kidney/k+ interaction as NSAIDs.
Which “anti-inflammatory” are you using? (NSAIDs vs steroids)
Different categories interact differently:
NSAIDs (ibuprofen, naproxen, diclofenac)
These are the biggest concern with ACE inhibitors. If you do use them, it’s best to:
- Use the lowest dose for the shortest time
- Avoid dehydration
- Ask your clinician/pharmacist whether you should have kidney function and potassium checked if you’ll use NSAIDs repeatedly.
Steroids (prednisolone, dexamethasone)
These can affect blood pressure, fluids, sugar, and electrolytes. They’re not the same interaction as NSAIDs, but your prescriber should know you’re taking them with an ACE inhibitor.
What should you do before combining them?
If you tell me:
1) the exact name on your prescription (and strength), and
2) the anti-inflammatory name (and dose),
I can give more specific guidance.
Until then, it’s safest to contact your pharmacist if you have any of these:
- reduced kidney function
- past high potassium
- age 65+
- you take a diuretic (like furosemide or hydrochlorothiazide) or spironolactone
- you’re on lithium or have heart failure
When to get urgent help
Seek urgent medical advice if, after starting the combination, you get:
- much less urine than usual
- swelling of face/lips
- severe dizziness/fainting
- weakness or palpitations (possible potassium issues)
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If you can reply with the exact spelling of the first drug (“Rimilpril” could be ramipril or another ACE inhibitor) and the anti-inflammatory you mean (ibuprofen? naproxen? diclofenac? prednisolone?), I’ll tailor the answer.