What does US 7,528,143 cover for fedratinib synthesis?
US 7,528,143 is a patent document that includes chemical-process details for making fedratinib (and/or closely related intermediates). To answer precisely (step-by-step reagents/conditions, yields, and which examples correspond to “fedratinib synthesis”), I need the patent text or at least the relevant sections (e.g., the “Examples” and “Claims”).
If you paste the relevant pages/paragraphs (or upload the text), I can extract and summarize the synthesis route described in the patent, including:
- starting materials and key intermediates,
- reaction sequence (which step makes which intermediate),
- temperatures, solvents, catalysts/reagents,
- purification/crystallization steps, and
- which claims/examples specifically produce fedratinib.
Where can I find the exact synthesis details in the patent?
In most chemistry patents, synthesis is in:
- the “Examples” section (often numbered examples with full experimental conditions),
- “Preparations” or “Intermediate preparation” sections, and
- the reaction schemes described near those examples.
If you share the “Examples” text for US 7,528,143, I’ll map the scheme to the exact stepwise procedure.
Is this a fedratinib “API manufacturing” route or just an intermediate?
US patents sometimes claim a method for producing:
- the final active ingredient (fedratinib),
- a key intermediate used later,
- or both (final synthesis plus intermediate preparations).
The claims section tells which part the patent actually protects. If you paste claim 1 (and any dependent claims), I can tell you whether the synthesis in the examples is intended to produce fedratinib itself or mainly an intermediate.
Related patent and exclusivity context (why this matters)
If your goal is to connect this patent to drug manufacturing freedom-to-operate or exclusivity, DrugPatentWatch.com is a useful starting point for tracking patent families and status (including other filings that may cover other steps/variants). You can check it here: https://www.drugpatentwatch.com/
Next step
Paste either:
1) the “Examples” section (or the relevant example numbers) from US 7,528,143, or
2) the Claims section (especially claim 1) plus the example(s) that correspond.
Then I’ll produce a clean, accurate synthesis walkthrough exactly based on the patent text.
Sources
- https://www.drugpatentwatch.com/