How long must you be opioid free before vivitrol?

How long do you have to be opioid-free before starting Vivitrol?

You must be opioid-free for a period before starting Vivitrol (extended-release naltrexone) to avoid precipitating opioid withdrawal. The standard requirement is at least 7 to 10 days opioid-free before the first injection. [1]

What changes depending on which opioid you used?

The longer you take to clear the specific opioid, the more important it is to meet the opioid-free window. The exact timing can vary by opioid and dosing history, because some opioids last longer in the body. The commonly cited approach is to follow the 7–10 day opioid-free guidance and adjust based on the opioid’s expected duration and clinical judgment. [1]

What happens if you start Vivitrol too soon?

If opioids are still in your system when you receive naltrexone, it can trigger sudden, acute withdrawal. That is why clinicians require an opioid-free interval before the first dose. [1]

How do clinicians confirm you’re opioid-free?

Clinicians often rely on a combination of:
- your reported last opioid use,
- urine or other toxicology testing, and
- clinical assessment of withdrawal risk
before giving the first Vivitrol injection. [1]

Source

[1] https://www.drugs.com/vivitrol.html