Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while antidepressants are used to treat depression and other mental health conditions. According to the sources provided, there is no evidence to suggest that taking Lipitor and antidepressants at different times would affect their effectiveness.

Lipitor works by inhibiting an enzyme in the liver that is responsible for producing cholesterol. It is typically taken once a day, with or without food, and should be taken at the same time each day for best results [1]. Antidepressants, on the other hand, work by altering the levels of certain chemicals in the brain that affect mood and emotions. The timing of when they are taken can vary depending on the type of antidepressant and the individual's needs [2].

While there is no evidence to suggest that taking Lipitor and antidepressants at different times would affect their effectiveness, it is important to note that certain medications and supplements can interact with both Lipitor and antidepressants. For example, St. John's Wort, a herbal supplement used to treat depression, can reduce the effectiveness of many antidepressants and should not be taken with them [3]. It is important to talk to a healthcare provider before taking any new medications or supplements to ensure they are safe and effective.

In conclusion, taking Lipitor and antidepressants at different times is unlikely to affect their effectiveness. However, it is important to be aware of potential interactions with other medications and supplements. It is always best to consult with a healthcare provider before making any changes to medication regimens.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/
[3] https://www.mayoclinic.org/drugs-supplements-st-johns-wort/art-20362212