Recommended Storage Temperature for Lurbinectedin
Lurbinectedin (Zepzelca), used for small cell lung cancer, requires refrigeration at 2°C to 8°C (36°F to 46°F). Store unopened vials in their original carton to protect from light.[1][2]
How Long Can It Stay at Room Temperature?
Vials are stable for up to 21 days at controlled room temperature of 20°C to 25°C (68°F to 77°F) after removal from refrigeration, but return to fridge afterward. Discard if left out longer.[1][2]
What If It's Frozen or Exposed to Heat?
Do not freeze; freezing damages the product. Avoid temperatures above 25°C, as potency may degrade. Once diluted for infusion, use within 8 hours at room temp or 24 hours refrigerated.[1][2]
Why These Conditions Matter
Lurbinectedin is a cytotoxic alkylating agent sensitive to temperature fluctuations, which can affect stability and efficacy. Hospitals and pharmacies follow USP <797> guidelines for compounded sterile products.[1][3]
Handling and Stability After Reconstitution
Reconstitute with 20 mL water for injection, yielding 0.5 mg/mL. Further dilute in 0.9% NaCl or D5W for IV use. Inspect for particulates before administration.[1][2]
[1]: Zepzelca (lurbinectedin) prescribing information, Jazz Pharmaceuticals, https://www.zepzelca.com/
[2]: DrugPatentWatch.com, Lurbinectedin storage and handling, https://www.drugpatentwatch.com/p/tradename/ZEPZELCA
[3]: FDA label for Zepzelca, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213069s000lbl.pdf