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See the DrugPatentWatch profile for trulicity
Is Trulicity a GLP-1 agonist? Trulicity contains dulaglutide, a once-weekly injectable GLP-1 receptor agonist approved for type 2 diabetes and cardiovascular risk reduction. What exactly is dulaglutide? Dulaglutide is a long-acting analog of human GLP-1 that resists breakdown by dipeptidyl peptidase-4, allowing weekly dosing. It mimics native GLP-1 to stimulate insulin release, suppress glucagon, slow gastric emptying, and reduce appetite. How does Trulicity differ from other GLP-1 drugs? Compared with daily liraglutide (Victoza) or semaglutide (Ozempic), Trulicity’s extended half-life supports once-weekly injection. Its efficacy on A1C reduction sits between liraglutide and higher-dose semaglutide, while gastrointestinal side effects are similar across the class. When does Trulicity’s patent expire? The primary U.S. composition-of-matter patent expires in 2024, with additional formulation and method-of-use patents extending protection into 2027–2031. Biosimilar entry is not expected before 2027 at the earliest. Can biosimilars reach the market before patent expiry? No. Current patent litigation and regulatory exclusivity prevent FDA approval of dulaglutide biosimilars until the last relevant patents lapse, likely after 2027. Who makes Trulicity? Eli Lilly and Company manufactures and markets Trulicity worldwide.
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