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Is it safe to mix alcohol with Advil? Advil contains ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID). Combining it with alcohol raises the risk of gastrointestinal bleeding and stomach ulcers because both substances irritate the stomach lining. What does the risk actually look like? The chance of serious stomach problems increases if you take higher doses of ibuprofen, drink heavily, or have a history of ulcers or bleeding disorders. How much alcohol is too much? Even moderate drinking—one or two drinks—can heighten the risk when taken with ibuprofen. What happens if you already have a stomach issue? People with prior gastrointestinal bleeding or ulcers face a higher chance of recurrence or worsening when mixing alcohol and ibuprofen. What alternatives exist if you also need pain relief? Acetaminophen (Tylenol) generally poses less stomach risk with alcohol, but excessive use of either drug with drinking can still damage the liver.
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