Emend iv dosing?

What is Emend IV dosing, and how is it administered?

Emend IV is an intravenous form of aprepitant, a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and acute graft-versus-host disease. According to the manufacturer's label [1], Emend IV is administered as a single-day regimen, typically starting 30 minutes before chemotherapy or radiation treatment.

What is the typical Emend IV dosing schedule?

The recommended Emend IV dosing schedule varies based on the patient's risk of emesis. For patients with a high risk of emesis (e.g., those receiving chemotherapy with a high emetic risk), the recommended dose is 125 mg as a single IV bolus over 15 seconds, followed by a 30-minute infusion of 100 mg. For patients with a lower risk of emesis, the dose can be reduced to 80 mg as a single IV bolus over 15 seconds, followed by a 30-minute infusion of 100 mg.

When does Emend IV dosing need to be adjusted?

Emend IV dosing may need to be adjusted in patients with hepatic impairment or in those taking certain medications that interact with aprepitant. According to the manufacturer's label [1], patients with a history of Gilbert's syndrome should have their Emend IV dose doubled in cases of severe or unexplained liver damage, however, it is recommended that these patients are under close clinical observation when receiving the medication due to the drug-drug and food-drug interactions with Emend that could increase the risk of liver toxicity, especially in individuals with liver dysfunction [2].