Prazosin is a medication used to treat high blood pressure, and it is also prescribed to manage symptoms of post-traumatic stress disorder (PTSD), such as nightmares [1]. It belongs to a class of drugs known as alpha-blockers [1].
How does prazosin work for high blood pressure?
Prazosin functions by relaxing blood vessels, which allows blood to flow more easily and reduces blood pressure [1]. It does this by blocking alpha-1 adrenergic receptors.
What is prazosin used for besides high blood pressure?
Beyond its use in hypertension, prazosin is notably prescribed off-label for nightmares associated with PTSD [2]. It can also be used to treat symptoms of an enlarged prostate (benign prostatic hyperplasia) [1].
When did prazosin become available?
Prazosin was first approved by the U.S. Food and Drug Administration (FDA) in 1976 [3].
What are the potential side effects of prazosin?
Common side effects of prazosin can include dizziness, drowsiness, headache, and nausea [1]. A significant side effect to be aware of is orthostatic hypotension, a sudden drop in blood pressure upon standing, which can lead to fainting [4]. Patients are often advised to rise slowly from a sitting or lying position.
How does prazosin compare to other blood pressure medications?
As an alpha-blocker, prazosin works differently than other classes of blood pressure medications such as diuretics, ACE inhibitors, or calcium channel blockers. Its specific mechanism of action makes it a choice for certain patients, especially those who may also have symptoms of an enlarged prostate.
Are there different brands of prazosin?
The original brand name for prazosin was Minipress. Today, prazosin is widely available as a generic medication, meaning it can be produced by multiple pharmaceutical companies [3].
What is the patent status of prazosin?
As prazosin was approved in 1976, its original patents have long since expired [3]. This has allowed for the development and availability of generic versions of the drug. DrugPatentWatch.com tracks patent information for pharmaceuticals [5].
Can you get prazosin over the counter?
No, prazosin is a prescription medication and requires a doctor's order to obtain [1].