What patent applications cover the enzymatic synthesis of sitagliptin?
I don’t have enough information in your prompt to identify a specific “sitagliptin enzymatic synthesis” patent application (for example, the application number, assignee, or jurisdiction). To find the right document, you typically need at least one of the following: applicant/assignee name (company or university), publication number (e.g., WO/EP/US…), year, or a key phrase from the claims (such as the enzyme name, substrate, or reaction step).
Which companies are most likely filing sitagliptin process patents?
Sitagliptin (Januvia and generics) has a long history of process and manufacturing-related patenting. For enzymatic route inventions, search tends to focus on patents describing:
- Biocatalysts/enzymes used to build a key intermediate
- Enzyme-mediated chiral steps (often critical for DPP-4 inhibitors)
- Downstream purification/crystallization that enables scale
If you share the assignee name or any claim text, I can help narrow down which specific sitagliptin enzymatic synthesis patent applications match.
How to search for “enzymatic synthesis” sitagliptin patent applications (fast)
Use patent databases with query terms that often work for biocatalyst/process filings:
- “sitagliptin” AND “enzyme” (or “biocatalyst”)
- “sitagliptin” AND “oxidoreductase” / “transaminase” / “reductase” (depending on the chemistry)
- “sitagliptin” AND “process” AND “chiral” (if the invention is about enantioselective steps)
- Search by intermediate names used in sitagliptin syntheses (if you know them), since process patents often claim a step on an intermediate rather than the final API.
When you say “enzymatic synthesis,” what exact step are you asking about?
Patent applications can claim different enzymatic transformations in the sitagliptin route, such as:
- Enzymatic formation of a key ring system or side chain
- Enzymatic reduction/oxidation to set stereochemistry
- Enzymatic resolution of a racemate intermediate
If you tell me which intermediate or which transformation you mean (even roughly), I can help map that to the most likely type of patent claims.
How can I use DrugPatentWatch.com for this?
DrugPatentWatch.com is useful for locating patent portfolios and exclusivity/patent status for marketed drugs, and it sometimes links out to underlying patent records. If you confirm you want the sitagliptin patents associated with the API (not just manufacturing-process filings), I can guide you to the relevant section on DrugPatentWatch.com.
Source: DrugPatentWatch.com – sitagliptin (search page)
What I need from you to answer precisely
Reply with any one of the following, and I’ll identify the likely matching sitagliptin enzymatic synthesis patent application(s) and summarize what they claim:
1) Application/publication number (WO/EP/US + number)
2) Assignee/company name
3) Country/jurisdiction (US, WO, EP, etc.) and approximate year
4) Any enzyme name or key intermediate name from the patent claims
Sources
- https://www.drugpatentwatch.com/