Advil is a brand name for the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen [1]. Warfarin is an anticoagulant medication that works by inhibiting the production of clotting factors in the liver [2]. The interaction between Advil and warfarin is a concern because Advil can increase the risk of bleeding when taken with warfarin [3].

A study published in the Journal of Clinical Pharmacology found that ibuprofen can increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding [2]. This effect was seen even with low doses of ibuprofen and was more pronounced in older adults.

The Harvard Health Letter advises caution when taking NSAIDs like Advil with warfarin, as these medications can increase the risk of bleeding and potentially lead to serious complications like gastrointestinal bleeding or hemorrhagic stroke [3].

It is important for patients taking warfarin to talk to their healthcare provider before taking any new medications, including over-the-counter medications like Advil. If pain relief is needed, acetaminophen (Tylenol) may be a safer option for patients taking warfarin [3].

In summary, Advil (ibuprofen) can increase the risk of bleeding when taken with warfarin, an anticoagulant medication. Patients taking warfarin should talk to their healthcare provider before taking any new medications and may consider acetaminophen as a safer option for pain relief [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://pubmed.ncbi.nlm.nih.gov/2783873/
[3] https://www.health.harvard.edu/heart-health/ask-the-doctor-arthritis-pain-relief-while-taking-warfarin