Dextroamphetamine 5 mg tablets are a prescription stimulant used mainly for ADHD and, in some cases, narcolepsy. It’s the right-hand (d) enantiomer of amphetamine and is sold under brand names like Dexedrine or Zenzedi (immediate-release). It’s a Schedule II controlled substance in the US.
What it is and what it’s used for
- Indications: ADHD (in children, teens, and adults) and narcolepsy. Not approved for weight loss in many places today.
- Form: 5 mg immediate-release tablets are common. There are also 5 mg/10 mg tablets and extended-release forms (with different dosing).
How it’s taken
- Dosing is individualized and prescribed by a clinician.
- Common starting approach (for ADHD with IR 5 mg): 5 mg once daily in the morning; may be increased gradually (often by 5 mg per week) based on response and tolerability.
- Some people split doses (e.g., 5 mg in the morning and 5 mg later in the day) depending on symptoms and sleep.
- Do not chew or crush extended-release forms unless your doctor tells you to; swallow IR tablets whole with water.
- Take in the morning or early afternoon to minimize insomnia; avoid late-day dosing.
Common side effects
- Weight loss, decreased appetite, stomach upset
- Insomnia or restlessness
- Dry mouth
- Increased heart rate or blood pressure, dizziness
- Anxiety or irritability
- In some people, mood changes or worsening tics
Serious but less common risks
- High blood pressure or heart rhythm problems
- Chest pain or shortness of breath
- New or worsening psychiatric symptoms (agitation, paranoia, hallucinations)
- Dependence, abuse, or withdrawal symptoms if stopped abruptly
Important interactions and precautions
- Avoid with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.
- Can interact with other stimulants, caffeine, or drugs that raise blood pressure or heart rate.
- Not recommended in certain conditions unless a clinician approves: significant heart disease, uncontrolled hypertension, severe anxiety or psychosis, glaucoma, hyperthyroidism, or a history of substance abuse.
- Pregnancy and breastfeeding: discuss with a clinician as there are potential risks.
- Keep in a secure place out of reach of children; it’s a controlled substance.
What to do if you’re taking it
- Take exactly as prescribed. If you miss a dose, don’t double up; skip it if it’s near bedtime.
- Monitor your weight, appetite, sleep, and mood. Report any chest pain, severe anxiety, mood changes, or trouble sleeping to your clinician.
- Don’t stop suddenly without medical advice; some people may need a tapered cessation.
If you’d like, tell me:
- Are you looking for dosing guidance, side effects, interactions, or how it compares to other ADHD meds like Adderall?
- Do you have a prescription, or are you seeking general information?
- Any medical history I should consider (heart problems, anxiety, thyroid issues, pregnancy, etc.)?