Standard Storage for Novarel
Novarel, a brand of human chorionic gonadotropin (hCG) used for fertility treatments, comes as a lyophilized powder that requires reconstitution with a diluent like bacteriostatic water before use. Store unreconstituted vials at room temperature (20-25°C or 68-77°F), protected from light. Avoid freezing or refrigeration, as extremes can degrade the hormone.[1][2]
After Reconstitution
Once mixed, refrigerate the solution at 2-8°C (36-46°F) and use within 30-60 days, depending on the diluent—bacteriostatic water extends shelf life compared to sterile water. Do not freeze the reconstituted product, and discard if it becomes cloudy or discolored.[1][3]
Travel and Handling Tips
For short-term travel, unreconstituted vials remain stable at room temperature for up to 30 days. Keep away from direct sunlight and heat sources like car dashboards. Patients often use cooler bags with ice packs for reconstituted doses during injections.[2][4]
What If Improperly Stored?
Exposure to temperatures above 25°C shortens potency; studies show hCG activity drops after prolonged heat. Freezing can cause precipitation upon thawing, rendering it ineffective. Always check expiration dates and consult a pharmacist for compromised vials.[3][5]
Manufacturer Guidelines
Ferring Pharmaceuticals, Novarel's maker, specifies these conditions in the package insert to maintain sterility and efficacy. For the latest, refer to the official prescribing information.[1]
Sources:
[1]: Novarel Package Insert (Ferring)
[2]: Drugs.com - Novarel Storage
[3]: FDA Label for Novarel
[4]: ASRM Fertility Medication Guidelines
[5]: PubMed - hCG Stability Study