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How long do side effects from Lipitor last? Side effects from Lipitor (atorvastatin) tend to last as long as the drug remains in the body. Atorvastatin has a half-life of 14 hours, so it takes about five half-lives, or roughly three days, for the drug itself to clear. However, some patients report muscle pain or weakness that persists longer than the time it takes for the drug to clear. Why do muscle effects linger? Some patients report muscle pain or weakness that persists longer than the time it takes for the atorvastatin to clear from the system. Muscle-related complaints can continue for weeks or months after stopping the drug. This occurs when the statin disrupts mitochondrial function in muscle cells, a process that may require time to reverse. What side effects are patients asking about? Patients commonly ask about muscle pain, weakness, memory problems, and liver enzyme changes. Muscle pain is the most frequent complaint. Memory problems and liver concerns can also arise, but they usually resolve once the drug is stopped. Can side effects return after stopping? Side effects do not return once the drug is stopped, unless the patient resumes taking it.
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