The question at hand is whether there is less resistance with higher tigecycline dosages. To answer this question, it is crucial to understand that bacterial resistance to antibiotics is a complex phenomenon influenced by various factors, and it is not solely determined by the dosage of the antibiotic alone [1].

Tigecycline is a broad-spectrum antibiotic, and like other antibiotics, its effectiveness can be compromised by bacterial resistance [2]. However, there is no direct evidence to suggest that higher tigecycline dosages result in less resistance [3].

In fact, a study published in the Journal of Antimicrobial Chemotherapy found that increasing the dosage of tigecycline did not necessarily lead to improved clinical outcomes in patients with severe infections [4]. This suggests that dosage alone may not be the primary factor in overcoming bacterial resistance to tigecycline.

It is important to note that the development of antibiotic resistance is a significant global health concern, and the overuse or misuse of antibiotics can contribute to the emergence and spread of resistant bacteria [5]. Therefore, it is essential to use antibiotics, including tigecycline, judiciously and in accordance with established guidelines to minimize the risk of resistance [6].

In summary, there is no direct evidence to suggest that higher tigecycline dosages result in less resistance. Bacterial resistance to antibiotics is a complex phenomenon influenced by various factors, and it is not solely determined by the dosage of the antibiotic alone. The prudent use of antibiotics, including tigecycline, is crucial to minimize the risk of resistance.

Sources:
[1] https://www.ncbi.nlm.nih.gov/books/NBK214540/
[2] https://www.ncbi.nlm.nih.gov/books/NBK538153/
[3] https://www.drugpatentwatch.com/drugs/tigecycline
[4] https://academic.oup.com/jac/article/64/9/2055/1017847
[5] https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
[6] https://www.cdc.gov/antibiotic-use/judicious-use/index.html