What is Accrufer (ferric maltol) and what does “noael” mean here?
Accrufer is a brand of ferric maltol, an oral medicine used to treat iron deficiency when patients need oral iron therapy. It is not an animal-safety label term by itself.
“NOAEL” typically stands for No Observed Adverse Effect Level. It’s a toxicology benchmark used in preclinical studies to identify the highest dose at which no harmful effects are observed.
If you saw “Accrufer NOAEL” in a document (for example, a regulatory review, study report, or risk assessment), the NOAEL value would be tied to a specific study and route of exposure (oral vs. other), and usually to a species (rat, dog, etc.). Without the text you’re looking at, the exact NOAEL number can’t be confirmed from the information you provided.
Where do NOAEL values show up for Accrufer?
NOAEL values are usually reported in materials like:
- nonclinical toxicology study summaries (repeat-dose studies)
- risk assessments that convert NOAEL into human safety margins
- regulatory assessment reports
To find the correct Accrufer-specific NOAEL, you typically need one or more of these details:
- the study name or species (rat/dog)
- the dose range
- the endpoint used to define “adverse” (e.g., organ toxicity, body weight changes)
- whether it’s for systemic toxicity or a particular organ
What do NOAEL numbers mean for patient safety?
A NOAEL is used to help estimate a safe exposure level for humans by applying safety factors. The final human limits can also depend on:
- whether NOAEL is for the parent compound vs metabolites
- observed toxicology at higher doses (even if NOAEL was set)
- clinical pharmacokinetics (how much drug the body absorbs)
Can you share the document snippet you mean by “Accrufer noael”?
If you paste the sentence/table that includes “Accrufer” and “NOAEL” (or tell me the source such as EMA, FDA, or a specific study/report title), I can:
- extract the exact NOAEL value and units,
- explain what study it comes from,
- and translate how it’s used in the safety assessment.
If you want, also tell me whether you’re looking for NOAEL for repeat-dose toxicity, developmental toxicity, or another specific endpoint.